Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.8
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
8
Coenzyme Q10 effects on prostate cancer
We explored the effects of coenzyme Q10 on prostate cancer by investigating its impact on two cell lines: PNT2, which is non-cancerous, and PC3, which is cancerous. Our focus was on how this supplement influenced the levels of a specific protein called PHGPx and the production of reactive oxygen species (ROS), which are often linked to cancer progression.
We observed that the cancerous PC3 cells reacted quite differently to coenzyme Q10 compared to the non-cancerous PNT2 cells. There were no noticeable changes in the levels of PHGPx in the PC3 cells, yet we recorded a significant increase in ROS production. Additionally, coenzyme Q10 supplementation was found to reduce the growth of the cancerous PC3 line but did not impact the growth of the non-malignant PNT2 cells.
These findings suggest that coenzyme Q10 might offer a novel approach in cancer therapy, specifically for prostate cancer. However, further investigations are necessary to confirm these results before considering any clinical applications.
We observed that the cancerous PC3 cells reacted quite differently to coenzyme Q10 compared to the non-cancerous PNT2 cells. There were no noticeable changes in the levels of PHGPx in the PC3 cells, yet we recorded a significant increase in ROS production. Additionally, coenzyme Q10 supplementation was found to reduce the growth of the cancerous PC3 line but did not impact the growth of the non-malignant PNT2 cells.
These findings suggest that coenzyme Q10 might offer a novel approach in cancer therapy, specifically for prostate cancer. However, further investigations are necessary to confirm these results before considering any clinical applications.
Read More
4
We investigated the relationship between circulating levels of coenzyme Q10 (CoQ10) and the risk of developing prostate cancer. Using prediagnostic blood samples, we matched 307 prostate cancer cases with 596 controls based on factors like age, ethnicity, and geographic location, to ensure a robust comparison.
Our findings revealed no overall significant association between CoQ10 levels and prostate cancer risk, signaling that higher or lower levels did not show a definitive impact. Interestingly, when we excluded controls who might have had undiagnosed prostate cancer, the odds appeared more favorable for individuals with moderate CoQ10 levels, suggesting that these levels could be linked to potentially lower risk.
However, it's important to emphasize that these results were not statistically significant, meaning we cannot confidently assert a clear protective effect of CoQ10 against prostate cancer at this time. As this is the first epidemiologic study on this particular association, further research is warranted to clarify these findings and their implications for prostate cancer prevention strategies.
Understanding nutritional factors like CoQ10 that might influence such a common cancer could have substantial implications for public health, especially given the high incidence rates of prostate cancer.
Our findings revealed no overall significant association between CoQ10 levels and prostate cancer risk, signaling that higher or lower levels did not show a definitive impact. Interestingly, when we excluded controls who might have had undiagnosed prostate cancer, the odds appeared more favorable for individuals with moderate CoQ10 levels, suggesting that these levels could be linked to potentially lower risk.
However, it's important to emphasize that these results were not statistically significant, meaning we cannot confidently assert a clear protective effect of CoQ10 against prostate cancer at this time. As this is the first epidemiologic study on this particular association, further research is warranted to clarify these findings and their implications for prostate cancer prevention strategies.
Understanding nutritional factors like CoQ10 that might influence such a common cancer could have substantial implications for public health, especially given the high incidence rates of prostate cancer.
Read More
We systematically reviewed various lifestyle interventions, including dietary and nutritional changes, aimed at influencing prostate cancer progression and mortality. Among the interventions we examined were trials that integrated coenzyme Q10, often alongside other supplements like lycopene and selenium.
Notably, the trials incorporating coenzyme Q10 were part of a larger group of 44 randomized controlled studies involving a total of 3,418 prostate cancer patients from 13 countries. Although some trials showed beneficial effects on disease outcomes, the specific impact of coenzyme Q10 was hard to isolate, as it was paired with other supplements in the trials.
The results indicated that while several combinations yielded promising outcomes, many trials suffered from limitations such as small sample sizes, high risk of bias, or inadequate reporting, which prevent us from definitively concluding that coenzyme Q10 alone is effective against prostate cancer. In summary, we found that more robust, well-structured trials focusing on coenzyme Q10 would be necessary to clarify its role and effectiveness.
Notably, the trials incorporating coenzyme Q10 were part of a larger group of 44 randomized controlled studies involving a total of 3,418 prostate cancer patients from 13 countries. Although some trials showed beneficial effects on disease outcomes, the specific impact of coenzyme Q10 was hard to isolate, as it was paired with other supplements in the trials.
The results indicated that while several combinations yielded promising outcomes, many trials suffered from limitations such as small sample sizes, high risk of bias, or inadequate reporting, which prevent us from definitively concluding that coenzyme Q10 alone is effective against prostate cancer. In summary, we found that more robust, well-structured trials focusing on coenzyme Q10 would be necessary to clarify its role and effectiveness.
Read More
Most Useful Reviews
8
Increased energy focus
Doctor’s Best High Absorption CoQ10 with BioPerine is superb! I've noted increased energy, improved focus, and reduced mental fog. It enhances my overall wellbeing and supports my body. CoQ10 is an antioxidant that defends against free radical damage while BioPerine may help combat the growth of cancer cells and aids nutrient absorption.
Read More
7.5
Effective for prevention
1 people found this helpful
Coenzyme Q10 prevents plaque formation in the veins, effectively reducing the risk of venous thrombosis. It has strong antioxidant properties, protecting cells from free radicals, which is excellent for cancer prevention. My skin condition also improves, becoming more elastic and moisturised.
Read More
7
Supports heart health
Coenzyme Q10, or ubiquinone, is vital for organs like the heart, liver, and brain that require substantial energy. Its antioxidant properties protect healthy cells from toxins, slowing down ageing and cancer development. This supplement positively impacts my health and happiness.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.8
- All Researches
8
Coenzyme Q10 effects on prostate cancer
We explored the effects of coenzyme Q10 on prostate cancer by investigating its impact on two cell lines: PNT2, which is non-cancerous, and PC3, which is cancerous. Our focus was on how this supplement influenced the levels of a specific protein called PHGPx and the production of reactive oxygen species (ROS), which are often linked to cancer progression.
We observed that the cancerous PC3 cells reacted quite differently to coenzyme Q10 compared to the non-cancerous PNT2 cells. There were no noticeable changes in the levels of PHGPx in the PC3 cells, yet we recorded a significant increase in ROS production. Additionally, coenzyme Q10 supplementation was found to reduce the growth of the cancerous PC3 line but did not impact the growth of the non-malignant PNT2 cells.
These findings suggest that coenzyme Q10 might offer a novel approach in cancer therapy, specifically for prostate cancer. However, further investigations are necessary to confirm these results before considering any clinical applications.
We observed that the cancerous PC3 cells reacted quite differently to coenzyme Q10 compared to the non-cancerous PNT2 cells. There were no noticeable changes in the levels of PHGPx in the PC3 cells, yet we recorded a significant increase in ROS production. Additionally, coenzyme Q10 supplementation was found to reduce the growth of the cancerous PC3 line but did not impact the growth of the non-malignant PNT2 cells.
These findings suggest that coenzyme Q10 might offer a novel approach in cancer therapy, specifically for prostate cancer. However, further investigations are necessary to confirm these results before considering any clinical applications.
Read More
We systematically reviewed various lifestyle interventions, including dietary and nutritional changes, aimed at influencing prostate cancer progression and mortality. Among the interventions we examined were trials that integrated coenzyme Q10, often alongside other supplements like lycopene and selenium.
Notably, the trials incorporating coenzyme Q10 were part of a larger group of 44 randomized controlled studies involving a total of 3,418 prostate cancer patients from 13 countries. Although some trials showed beneficial effects on disease outcomes, the specific impact of coenzyme Q10 was hard to isolate, as it was paired with other supplements in the trials.
The results indicated that while several combinations yielded promising outcomes, many trials suffered from limitations such as small sample sizes, high risk of bias, or inadequate reporting, which prevent us from definitively concluding that coenzyme Q10 alone is effective against prostate cancer. In summary, we found that more robust, well-structured trials focusing on coenzyme Q10 would be necessary to clarify its role and effectiveness.
Notably, the trials incorporating coenzyme Q10 were part of a larger group of 44 randomized controlled studies involving a total of 3,418 prostate cancer patients from 13 countries. Although some trials showed beneficial effects on disease outcomes, the specific impact of coenzyme Q10 was hard to isolate, as it was paired with other supplements in the trials.
The results indicated that while several combinations yielded promising outcomes, many trials suffered from limitations such as small sample sizes, high risk of bias, or inadequate reporting, which prevent us from definitively concluding that coenzyme Q10 alone is effective against prostate cancer. In summary, we found that more robust, well-structured trials focusing on coenzyme Q10 would be necessary to clarify its role and effectiveness.
Read More
4
We investigated the relationship between circulating levels of coenzyme Q10 (CoQ10) and the risk of developing prostate cancer. Using prediagnostic blood samples, we matched 307 prostate cancer cases with 596 controls based on factors like age, ethnicity, and geographic location, to ensure a robust comparison.
Our findings revealed no overall significant association between CoQ10 levels and prostate cancer risk, signaling that higher or lower levels did not show a definitive impact. Interestingly, when we excluded controls who might have had undiagnosed prostate cancer, the odds appeared more favorable for individuals with moderate CoQ10 levels, suggesting that these levels could be linked to potentially lower risk.
However, it's important to emphasize that these results were not statistically significant, meaning we cannot confidently assert a clear protective effect of CoQ10 against prostate cancer at this time. As this is the first epidemiologic study on this particular association, further research is warranted to clarify these findings and their implications for prostate cancer prevention strategies.
Understanding nutritional factors like CoQ10 that might influence such a common cancer could have substantial implications for public health, especially given the high incidence rates of prostate cancer.
Our findings revealed no overall significant association between CoQ10 levels and prostate cancer risk, signaling that higher or lower levels did not show a definitive impact. Interestingly, when we excluded controls who might have had undiagnosed prostate cancer, the odds appeared more favorable for individuals with moderate CoQ10 levels, suggesting that these levels could be linked to potentially lower risk.
However, it's important to emphasize that these results were not statistically significant, meaning we cannot confidently assert a clear protective effect of CoQ10 against prostate cancer at this time. As this is the first epidemiologic study on this particular association, further research is warranted to clarify these findings and their implications for prostate cancer prevention strategies.
Understanding nutritional factors like CoQ10 that might influence such a common cancer could have substantial implications for public health, especially given the high incidence rates of prostate cancer.
Read More
We aimed to understand how a combination of dietary supplements, including coenzyme Q10, affects prostate cancer indicators, specifically serum PSA levels. In our study, eighty patients diagnosed with hormonally untreated prostate cancer participated. Half of the group received a daily supplement containing vitamin E, selenium, vitamin C, and coenzyme Q10, while the other half received a placebo for a duration of 21 weeks.
Throughout the study, we measured various serum biomarkers at different intervals to see if there were any notable changes. While we found that compliance among participants was high and levels of vitamins did rise in the supplement group, there were no significant differences in PSA levels or other hormone levels between those taking the supplement and those on placebo.
Ultimately, we observed that adding coenzyme Q10, along with other vitamins, did not significantly impact prostate cancer progression as indicated by serum PSA levels. This suggests that this specific combination of supplements may not be effective in altering the course of prostate disease in hormonally untreated patients.
Throughout the study, we measured various serum biomarkers at different intervals to see if there were any notable changes. While we found that compliance among participants was high and levels of vitamins did rise in the supplement group, there were no significant differences in PSA levels or other hormone levels between those taking the supplement and those on placebo.
Ultimately, we observed that adding coenzyme Q10, along with other vitamins, did not significantly impact prostate cancer progression as indicated by serum PSA levels. This suggests that this specific combination of supplements may not be effective in altering the course of prostate disease in hormonally untreated patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
8
Increased energy focus
Doctor’s Best High Absorption CoQ10 with BioPerine is superb! I've noted increased energy, improved focus, and reduced mental fog. It enhances my overall wellbeing and supports my body. CoQ10 is an antioxidant that defends against free radical damage while BioPerine may help combat the growth of cancer cells and aids nutrient absorption.
Read More
7.5
Effective for prevention
1 people found this helpful
Coenzyme Q10 prevents plaque formation in the veins, effectively reducing the risk of venous thrombosis. It has strong antioxidant properties, protecting cells from free radicals, which is excellent for cancer prevention. My skin condition also improves, becoming more elastic and moisturised.
Read More
7
Supports heart health
Coenzyme Q10, or ubiquinone, is vital for organs like the heart, liver, and brain that require substantial energy. Its antioxidant properties protect healthy cells from toxins, slowing down ageing and cancer development. This supplement positively impacts my health and happiness.
Read More
Frequently Asked Questions
8
Increased energy focus
Doctor’s Best High Absorption CoQ10 with BioPerine is superb! I've noted increased energy, improved focus, and reduced mental fog. It enhances my overall wellbeing and supports my body. CoQ10 is an antioxidant that defends against free radical damage while BioPerine may help combat the growth of cancer cells and aids nutrient absorption.
7.5
Effective for prevention
1 people found this helpful
Coenzyme Q10 prevents plaque formation in the veins, effectively reducing the risk of venous thrombosis. It has strong antioxidant properties, protecting cells from free radicals, which is excellent for cancer prevention. My skin condition also improves, becoming more elastic and moisturised.
7
Supports heart health
Coenzyme Q10, or ubiquinone, is vital for organs like the heart, liver, and brain that require substantial energy. Its antioxidant properties protect healthy cells from toxins, slowing down ageing and cancer development. This supplement positively impacts my health and happiness.
We systematically reviewed various lifestyle interventions, including dietary and nutritional changes, aimed at influencing prostate cancer progression and mortality. Among the interventions we examined were trials that integrated coenzyme Q10, often alongside other supplements like lycopene and selenium.
Notably, the trials incorporating coenzyme Q10 were part of a larger group of 44 randomized controlled studies involving a total of 3,418 prostate cancer patients from 13 countries. Although some trials showed beneficial effects on disease outcomes, the specific impact of coenzyme Q10 was hard to isolate, as it was paired with other supplements in the trials.
The results indicated that while several combinations yielded promising outcomes, many trials suffered from limitations such as small sample sizes, high risk of bias, or inadequate reporting, which prevent us from definitively concluding that coenzyme Q10 alone is effective against prostate cancer. In summary, we found that more robust, well-structured trials focusing on coenzyme Q10 would be necessary to clarify its role and effectiveness.
Notably, the trials incorporating coenzyme Q10 were part of a larger group of 44 randomized controlled studies involving a total of 3,418 prostate cancer patients from 13 countries. Although some trials showed beneficial effects on disease outcomes, the specific impact of coenzyme Q10 was hard to isolate, as it was paired with other supplements in the trials.
The results indicated that while several combinations yielded promising outcomes, many trials suffered from limitations such as small sample sizes, high risk of bias, or inadequate reporting, which prevent us from definitively concluding that coenzyme Q10 alone is effective against prostate cancer. In summary, we found that more robust, well-structured trials focusing on coenzyme Q10 would be necessary to clarify its role and effectiveness.
4
We investigated the relationship between circulating levels of coenzyme Q10 (CoQ10) and the risk of developing prostate cancer. Using prediagnostic blood samples, we matched 307 prostate cancer cases with 596 controls based on factors like age, ethnicity, and geographic location, to ensure a robust comparison.
Our findings revealed no overall significant association between CoQ10 levels and prostate cancer risk, signaling that higher or lower levels did not show a definitive impact. Interestingly, when we excluded controls who might have had undiagnosed prostate cancer, the odds appeared more favorable for individuals with moderate CoQ10 levels, suggesting that these levels could be linked to potentially lower risk.
However, it's important to emphasize that these results were not statistically significant, meaning we cannot confidently assert a clear protective effect of CoQ10 against prostate cancer at this time. As this is the first epidemiologic study on this particular association, further research is warranted to clarify these findings and their implications for prostate cancer prevention strategies.
Understanding nutritional factors like CoQ10 that might influence such a common cancer could have substantial implications for public health, especially given the high incidence rates of prostate cancer.
Our findings revealed no overall significant association between CoQ10 levels and prostate cancer risk, signaling that higher or lower levels did not show a definitive impact. Interestingly, when we excluded controls who might have had undiagnosed prostate cancer, the odds appeared more favorable for individuals with moderate CoQ10 levels, suggesting that these levels could be linked to potentially lower risk.
However, it's important to emphasize that these results were not statistically significant, meaning we cannot confidently assert a clear protective effect of CoQ10 against prostate cancer at this time. As this is the first epidemiologic study on this particular association, further research is warranted to clarify these findings and their implications for prostate cancer prevention strategies.
Understanding nutritional factors like CoQ10 that might influence such a common cancer could have substantial implications for public health, especially given the high incidence rates of prostate cancer.
We aimed to understand how a combination of dietary supplements, including coenzyme Q10, affects prostate cancer indicators, specifically serum PSA levels. In our study, eighty patients diagnosed with hormonally untreated prostate cancer participated. Half of the group received a daily supplement containing vitamin E, selenium, vitamin C, and coenzyme Q10, while the other half received a placebo for a duration of 21 weeks.
Throughout the study, we measured various serum biomarkers at different intervals to see if there were any notable changes. While we found that compliance among participants was high and levels of vitamins did rise in the supplement group, there were no significant differences in PSA levels or other hormone levels between those taking the supplement and those on placebo.
Ultimately, we observed that adding coenzyme Q10, along with other vitamins, did not significantly impact prostate cancer progression as indicated by serum PSA levels. This suggests that this specific combination of supplements may not be effective in altering the course of prostate disease in hormonally untreated patients.
Throughout the study, we measured various serum biomarkers at different intervals to see if there were any notable changes. While we found that compliance among participants was high and levels of vitamins did rise in the supplement group, there were no significant differences in PSA levels or other hormone levels between those taking the supplement and those on placebo.
Ultimately, we observed that adding coenzyme Q10, along with other vitamins, did not significantly impact prostate cancer progression as indicated by serum PSA levels. This suggests that this specific combination of supplements may not be effective in altering the course of prostate disease in hormonally untreated patients.
References
- Hackshaw-McGeagh LE, Perry RE, Leach VA, Qandil S, Jeffreys M, et al. A systematic review of dietary, nutritional, and physical activity interventions for the prevention of prostate cancer progression and mortality. Cancer Causes Control. 2015;26:1521. 10.1007/s10552-015-0659-4
- Chai W, Cooney RV, Franke AA, Caberto CP, Wilkens LR, et al. Plasma coenzyme Q10 levels and prostate cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2011;20:708. 10.1158/1055-9965.EPI-10-1309
- Hoenjet KM, Dagnelie PC, Delaere KP, Wijckmans NE, Zambon JV, et al. Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: a randomised placebo-controlled study. Eur Urol. 2005;47:433.
- Quiles JL, Farquharson AJ, Ramírez-Tortosa MC, Grant I, Milne L, et al. Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells. Biofactors. 2003;18:265.
